ditert-butyl indole-1,5-dicarboxylate
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester
CAS: 866587-85-1
Molecular Formula: C18H23NO4
ditert-butyl indole-1,5-dicarboxylate - Names and Identifiers
ditert-butyl indole-1,5-dicarboxylate - Physico-chemical Properties
| Molecular Formula | C18H23NO4 |
| Molar Mass | 317.38 |
| Storage Condition | 2-8°C |
ditert-butyl indole-1,5-dicarboxylate - Introduction
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester, also known as 1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is a colorless to light yellow solid with low solubility. It is stable at room temperature, but may decompose when heated.
Use:
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is a common intermediate compound in organic synthesis. It is commonly used in the synthesis of drugs, pesticides and functional compounds. This compound is characterized by acid-catalyzed removal of N-tert-butoxycarbonyl (Boc) to give the N-H indole -5-carboxylic acid derivative.
Preparation Method:
The preparation of 1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is usually achieved by esterification of indole -5-carboxylic acid. One common method is to react indole -5-carboxylic acid with t-butanol and an active esterifying agent (e. g., 1-hydroxyphenyldimethylmethyl ester) in a suitable solvent to give 1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethyl) ester.
Safety Information:
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is generally less toxic under routine operation. However, as a chemical, care should be taken to comply with appropriate safety procedures, such as avoiding direct contact with skin and eyes, and avoiding inhalation of its dust or gas during operation. When using or storing the compound, keep the room well ventilated and store it in an airtight container. In case of any health problems or accidents, seek medical assistance immediately.
Nature:
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is a colorless to light yellow solid with low solubility. It is stable at room temperature, but may decompose when heated.
Use:
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is a common intermediate compound in organic synthesis. It is commonly used in the synthesis of drugs, pesticides and functional compounds. This compound is characterized by acid-catalyzed removal of N-tert-butoxycarbonyl (Boc) to give the N-H indole -5-carboxylic acid derivative.
Preparation Method:
The preparation of 1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is usually achieved by esterification of indole -5-carboxylic acid. One common method is to react indole -5-carboxylic acid with t-butanol and an active esterifying agent (e. g., 1-hydroxyphenyldimethylmethyl ester) in a suitable solvent to give 1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethyl) ester.
Safety Information:
1H-Indole-1,5-dicarboxylic acid, 1,5-bis(1,1-diMethylethyl) ester is generally less toxic under routine operation. However, as a chemical, care should be taken to comply with appropriate safety procedures, such as avoiding direct contact with skin and eyes, and avoiding inhalation of its dust or gas during operation. When using or storing the compound, keep the room well ventilated and store it in an airtight container. In case of any health problems or accidents, seek medical assistance immediately.
Last Update：2024-04-09 20:45:29
